Skip to main content

HiGlass

Description

HiGlass is a web-based viewer for genome interaction maps featuring synchronized navigation of multiple views as well as continuous zooming and panning for navigation across genomic loci and resolutions. It can be used for visual comparison of Hi-C and other genomic data from different experimental conditions to efficiently identify salient outcomes of experimental perturbations, generate new hypotheses, and share the results with the community.

Gallery

HiGlass provides synchronized navigation of multiple views showing matrices from different experimental conditions, types or cell lines.
HiGlass provides synchronized navigation of multiple views showing matrices from different experimental conditions, types or cell lines. Visualizations in HiGlass are highly customizeable with a variety of track types available for displaying genomic contact and other data. A comparison of the outputs of seven different TAD callers, shown in HiGlass. Customizeable view linking lets users dynamically create detail-overview arrangements for comparing datasets at varying scales. HiGlass now supports multi-vector data, shown here in a stacked bar track view.

Publications

Websites

Media

Nature News (2017) - TechBlog: HiPiler simplifies chromatin structure analysis
"Using bioinformatic algorithms, researchers can query chromatin-contact datasets to find all such structures. But these algorithms may return thousands of hits. How is a researcher to study them? Enter HiPiler. Developed by Gehlenborg’s lab in collaboration with the lab of Hanspeter Pfister at the John A. Paulson School of Engineering and Applied Sciences at Harvard, HiPiler excises these features and presents them on a canvas as miniature snippets — basically tiny segments of the full-sized contact map, which users can then organize, sort, and cluster based on parameters such as noise or location."
Nature News (2017) - Toolbox: Plot a course through the genome
"Inspired by Google Maps, a suite of tools is allowing researchers to chart the complex conformations of chromosomes."

Software

GitHub
Docker

Funding